氧化锆生物陶瓷的立体光固化制备及其力学与生物性能

Mechanical and Biological Properties of ZrO_(2) Bioceramics by Stereolithography Technique

制备了用于立体光固化技术(SL)的ZrO_(2)浆料,采用SL打印制备了ZrO_(2)生物陶瓷,研究了烧结样品的力学性能与生物相容性。经过不同温度烧结后,ZrO_(2)原粉中的m-ZrO_(2)均完成了向t-ZrO_(2)或c-ZrO_(2)的转变。随着烧结温度的提高,陶瓷致密化程度提高,气孔数量减少;当烧结温度继续提高时,晶粒尺寸继续增大且大小不均匀。当烧结温度从1450℃升高至1600℃时,ZrO_(2)生物陶瓷的维氏硬度和断裂韧性先增大后减小,且均在1500℃达到最大值,分别为14.87 GPa和6.73 MPa·m^(1/2),此时的线收缩率与相对密度分别为23.42%和97.32%。同时利用大鼠骨髓间充质干细胞(rBMSCs)进行体外细胞实验,证明了SL成形的ZrO_(2)生物陶瓷具有较好的生物相容性,在牙科修复中具有广阔的应用前景。

In order to use ZrO_(2) all-ceramic restorations in the dental field,ZrO_(2) slurry suitable for SL technology was obtained and ZrO_(2) bioceramic was prepared by SL.The mechanical properties and biocompatibility were investigated.The transformation from m-ZrO_(2) to t-ZrO_(2) or c-ZrO_(2) in the original ZrO_(2) powder was completed when sintered at different temperatures.The density of ceramic increases and the number of pores decreases as the sintering temperature increases,and the grain size increases and becomes uneven when the temperature further increases.The Vickers hardness and fracture toughness of ZrO_(2) bioceramic firstly increase and then decrease when the sintering temperature increases from 1450℃to 1600℃,and they reach their maximum values(i.e.,14.87 GPa and 6.73 MPa·m^(1/2))at 1500℃.The linear shrinkage and relative density are 23.42%and 97.32%,respectively.In addition,rat bone marrow mesenchymal stem cells(rBMSCs)were used for in vitro cell experiments,thus proving that ZrO_(2) bioceramic fabricated by SL technique have a good biocompatibility,which can have some application prospects in dental restoration.