福建省健康人群A群和C群流脑抗体水平分析

Analysis on antibody levels of serogroup A and C meningococcal meningitis of healthy population in Fujian,China

目的了解福建省健康人群A群和C群流脑抗体水平,为有效防控流脑提供科学依据。方法按分层随机抽样法采集15个年龄组健康人群1557人的血清标本,用酶联免疫吸附试验检测A群和C群抗体水平。结果A群流脑抗体阳性率为88.3%,平均浓度为6.35μg/ml;C群流脑抗体阳性率为50.7%,平均浓度为1.89μg/ml;不同年龄组A群、C群流脑抗体阳性率及平均浓度差异有统计学意义:A群、C群流脑抗体阳性率和抗体浓度最高均为6~11岁组,阳性率分别为97.3%和88.5%,抗体浓度分别为15.55μg/ml和8.12μg/ml;不同免疫剂次儿童的A群、C群抗体阳性率及平均浓度差异均有统计学意义,免疫剂次多者其抗体平均浓度也较高,两群抗体阳性率均随免疫剂次增加而增高。结论福建省健康人群中A群流脑抗体水平维持在较高水平,C群相对较低。应进一步加强脑膜炎球菌疫苗免疫效果研究。

Objective To study the antibody levels of serogroup A and C meningococcal meningitis of healthy population in Fujian and provide scientific evidence for the disease control and prevention.Methods Serum samples from 1557 healthy population were collected in 15 age groups according to stratified random sampling method.Antibody levels of serogroup A and C meningococcal meningitis were examined by enzyme-linked immunosorbent assay(ELISA).Results The positive rate of antibody of serogroup A was 88.3%and the mean antibody concentration was 6.35μg/ml,and the positive rate of antibody of serogroup C was 50.7%and the mean antibody concentration was 1.89μg/ml.There were significant differences in the positive rates and mean concentrations of antibody of serogroup A and C in age groups.The highest positive rates and mean antibody concentrations of serogroup A and C were in 6~11 age group(97.3%and 88.5%,15.55μg/ml and 8.12μg/ml,respectively).There were significant differences in positive rates and mean antibody concentrations of serogroup A and C in children with different immunization doses.The more immunization doses the higher mean antibody concentration,and the positive rate of antibody of serogroup A and C increased with the increasing immunization dose.Conclusion The antibody level of serogroup A meningococcal meningitis remains at a relative higher level,while the serogroup C was at relative lower level for healthy population in Fujian.The immunization effectiveness of meningococcal vaccine should be further studied in the future.