摘要
A recent study published in Nature by Kim et al.discovers that the CNMamide(CNMa)-CNMa receptor(CNMaR)axis plays a crucial regulatory role in response to deprivation of diet-and microbiome-derived amino acid in Drosophila.In detail,gut enterocytes detect and respond to protein limitation through upregulating CNMa expression and communicating with CNMaR-expressing neurons in the brain(Fig.1).
基金
This work was supported by grants from National Key Research and Development Project of China(2020YFA0509400,2020YFC2002705,2019YFC1709000)
Guangdong Basic and Applied Basic Research Foundation(2019B030302012),NSFC(81821002,81790251)
1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(ZYJC21004)
MDT program of State Administration of Traditional Chinese Medicine.
