摘要
Dear Editor,Gut associated lymphoid tissue(GALT)is the principal site where human immunodeficiency virus 1(HIV-1)replicates.CD4^(+) T cells residing in GALT are predominant targets of HIV-1 during the acute phase of infection.CD4^(+) T cells expressing a high level of gut-homing receptor integrin α4β7 are more susceptible to productive infection by HIV-1.
基金
This work was supported by grants from National Key Research and Development Program of China(2020YFA0509100)
National Natural Science Foundation of China(31830112,32030024,31525016 to J.F.C,31970702,31701219 to C.D.L.)
Program of Shanghai Academic Research Leader Research Program of the Chinese Academy of Sciences(XDA12010101)
the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020266)
the Young Elite Scientist Sponsorship Program by CAST(2019QNRC001)
National Ten Thousand Talents Program.The authors gratefully acknowledge the support of SA-SIBS scholarship program.We thank Prof.Brian Seed and Dr.Slim Sassi(Massachusetts General Hospital,Boston,USA)for providing the codon optimized MN gp120 plasmid.We thank Prof.Lu Lu and Master Miao Cao(Fudan University,Shanghai,China)for providing the plasmids expressing BG505 SOSIP.664,Furin,and PGT145 for the expression and purification of BG505 SOSIP.664 gp140 trimers.(19XD1404200)
Personalized Medicines-Molecular Signature-based Drug Discovery and Development,the Strategic Priority。
