摘要
Dear Editor,S phase kinase-associated protein 2(SKP2),a substrate recognition component of the SCFSKP2 ubiquitin ligase complex,plays an oncogenic role in tumorigenesis by targeting a variety of tumor suppressors(e.g.,p21,p27,and p130)for ubiquitina-tion and subsequent degradation.1 As a well-characterized oncoprotein,the aberrant expression and dysregulation of SKP2 are frequently observed in different human cancers.Given its critical role in governing tumorigenesis and progression,SKP2 has emerged as a potential pharmacological target for anticancer therapy.
基金
This work was supported by the following funds:The Chinese Minister of Science and Technology grant(2016YFA0501800)
National Natural Science Foundation of China(Grants 81625018,81802743,and 81820108022)
Program of Shanghai Academic/Technology Research Leader(18XD1403800)
Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056)
National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001).
