摘要
Dear Editor,Since the beginning of 2020,the Coronavirus(CoV)Disease 2019(COVID-19)pandemic has posed formidable challenges to public health security.The main protease(Mpro,3CLpro)of CoVs plays essential roles in viral replication,making them attractive targets for antiviral drug development.
基金
M.L.was funded by the NSFC(82073292,81622002,81861130368)
the SJTU Trans-med Awards Research,the Gaofeng Clinical Medicine Grant(828318)
the Shanghai Excellent Youth Academic Leader Program(20XD1422700)
the Shanghai Medical and Health Excellent Discipline Leader Development Plan(2018BR36)
Shanghai Collaborative Innovation Center for Translational Medicine(TM201902)
the Foundation of the National Facility for Translational Medicine(Shanghai)(TMSK-2020-003)
the Newton Advanced Fellowship,and the Samuel Waxman Cancer Research Foundation.H.Y.was funded by the Science and Technology Commission of Shanghai Municipality(20431900200)
the Department of Science and Technology of Guangxi Zhuang Autonomous Region(2020AB40007)
L.Z.was funded by the NSFC(31970165).
