摘要
Dear Editors,Oncoprotein PIM1 kinase participates in many important biological processes,such as cell proliferation,apoptosis,carcinogenesis and tumorigenesis,by phosphorylating cellular substrates.More recently,several groups discovered that PIM1 affects(+)ssRNA virus transcription and modulates virus infection,such as human rhinovirus(HRV)-16 and hepatitis C virus(HCV).2 We recently reported that PIM1 enhances EV-A71 IRES activity by regulating AUF1 translocation.
基金
The work was partially supported by grants from The Science Technology and Innovation Committee of Shenzhen Municipality[JCYJ20180507181627057]
grants from National Science Foundation of China[81671995]
the general research grant of Hong Kong[11100215]
and Strategic funds from City University of Hong Kong.
