摘要
Cell death and immune response are at the core of life.In past decades,the endoplasmic reticulum(ER)protein STING!(also known as STING or TMEM173)was found to play a fundamental role in the production of type I interferons(IFNs)and pro-inflammatory cytokines in response to DNA derived from invading microbial pathogens or damaged hosts by activating multiple transcription factors.In addition to this well-known function in infection,inflammation,and immunity,emerging evidence suggests that the STING 1-dependent signaling network is implicated in health and disease by regulating autophagic degradation or various cell death modalities(e.g.,apoptosis,necroptosis,pyroptosis,ferroptosis,mitotic cell death,and immunogenic cell death[ICD]).Here,we outline the latest advances in our understanding of the regulating mechanisms and signaling pathways of STING1 in autophagy and cell death,which may shed light on new targets for therapeutic interventions.
