Jagged1促进乳腺癌发生发展及远处转移的研究进展

Research progress of Jagged1 promoting the occurrence,development and distant metastasis of breast cancer

乳腺癌是一种严重危害女性身心健康的疾病。晚期乳腺癌患者的死亡在很大程度上归因于重要脏器的远处转移而非原发肿瘤。Jagged1(JAG1)作为Notch信号通路的重要配体之一,不仅表达于肿瘤细胞,亦可表达于肿瘤微环境中的间质细胞,通过激活Notch信号通路,促进乳腺癌的侵袭性进展与远处转移。本文就JAG1基因位置与JAG1蛋白的结构、JAG1促进乳腺癌远处转移相关机制、JAG1与乳腺癌脑转移、JAG1与乳腺癌骨转移及JAG1的靶向治疗等方面进行综合论述。

Breast cancer is a disease that seriously endangers women's physical and mental health.The death of patients with advanced breast cancer is largely due to distant metastasis of important organs rather than primary tumors.Jagged1(JAG1),as one of the important ligands of the Notch signaling pathway,is not only expressed in tumor cells but also expressed in cells in the tumor microenvironment.By activating the Notch signaling pathway,it promotes the aggressive progression and distant metastasis of breast cancer.This paper comprehensively discusses the location of the JAG1 gene and the structure of the JAG1 protein,the mechanism of JAG1 promoting distant metastasis of breast cancer,the mechanisms of JAG1 promoting breast cancer distant metastasis,brain metastasis,and bone metastasis as well as JAG1 targeted therapy.