肠道微生物影响结直肠癌化疗疗效的研究现状

Research status of intestinal microbes affecting the efficacy of chemotherapy for colorectal cancer

肠道微生物是一个与机体健康密切相关的“生态系统”。一方面,肠道微生物可以为机体提供营养物质、参与机体新陈代谢和免疫调节,抵御病原体、发挥生物屏障功能等。另一方面,肠道微生物及其代谢产物可参与结直肠癌的发生,调节化疗药物及免疫检查点抑制剂作用机制,继而影响化疗及免疫治疗疗效、调节相关不良反应。基于既往大量肠道微生物研究及相关文献,本文将综述肠道微生物影响结直肠癌化疗药物作用机制、疗效的现状,其有望成为提高结直肠癌化疗疗效、降低药物毒副反应的新靶点。

Gut microbes are an“ecosystem”closely related to body health.On the one hand,intestinal microbes can provide nutrients for the body,participate in the body′s metabolism and immune regulation,resist pathogens,and exert biological barrier functions.On the other hand,intestinal microbes and their metabolites can participate in the occurrence of colorectal cancer,regulate the mechanism of chemotherapy drugs and immune checkpoint inhibitors,then affect the efficacy of chemotherapy and immunotherapy,and regulate related adverse reactions.Based on a large number of previous studies on intestinal microbes and related literatures,this article will review the current status of intestinal microbes affecting the mechanism and efficacy of chemotherapy drugs for colorectal cancer,which is expected to be a new target for improving the treatment of colorectal cancer and reducing the side reaction of the drug toxicity.