p16/Ki67表达与宫颈癌和癌前病变关系以及用于HPV阳性人群分流的诊断价值

Relationship Between p16/Ki67 Expression and Cervical Cancer&Precancerous Lesions,and its Diagnosis Value of HPV Positive Crowd Split

探讨p16、Ki67表达与宫颈癌和癌前病变的关系以及用于HPV阳性人群分流的诊断价值。选取244例女性为研究对象,所有对象均进行了HPV、p16、Ki16检测。p16与Ki67双染检测的阳性率与细胞学诊断级别上升呈正相关,细胞学病变级别增高与p16阳性率呈正相关。在HPV阳性人群分流中,p16、Ki67检测特异度显著高于p16/mc m2。p16、Ki67检测均可作为宫颈癌及癌前病变检出的潜在标志物,且在HPV检测阳性人群分流中,p16、Ki67的检测结果显著优于其它检测结果。

The research explores the relationship between p16 and Ki67 expression and cervical cancer&precancerous lesionsz,and its diagnosis value of HPV positive crowd split.244 women are selected as the research objects,and receive HPV,p16 and Ki16 testing.There is positive correlation between the positive rate under p16 and Ki67 double dye detection,and increased cytological diagnostic level,and between increased cytological diagnostic level and p16 positive rate.Among HPV positive crowd split,p16 and Ki67 testing specificity is significantly higher than p16/mc m2.Testing of p16 and Ki67 can be regarded as the potential landmark of cervical cancer and precancerous lesions.In HPV testing positive crowd split,the results of p16 and Ki67 are significantly better than other tests.