华法林药物基因组学的应用

Application of Warfarin Pharmacogenomics

华法林具有适应证广、经济且易于拮抗等优点,现已成为临床最常用的口服抗凝药物。但由于不同个体间药物剂量差异,导致其稳态剂量较难预测,造成过度抗凝、出血等不良事件的发生。随着近些年华法林代谢酶的基因组学研究,极大地推动了临床华法林精准治疗、个体化给药等的发展。本文就目前华法林基因组学及其临床应用进展进行阐述,以期为日后基因指导华法林的使用提供理论基础。

Warfarin has been the most commonly used oral anticoagulant drug in clinic because of its wide range of indications,economy and easy antagonism.However,due to the difference of drug dose among different individuals,the steady-state dose is difficult to predict,resulting in excessive anticoagulation,bleeding and other adverse events.In recent years,the genomics research of warfarin metabolic enzymes has greatly promoted the development of clinical warfarin precision therapy and individualized drug administration.In this paper,the genomics and clinical application of warfarin are reviewed,in order to provide a theoretical basis for the use of gene guidance warfarin in the future.