ICU中持续炎症反应-免疫抑制-分解代谢综合征的危险因素及治疗研究

Research on the Risk Factors and Treatment of Persistent Inflammation-immunosuppression-catabolism Syndrome in ICU

持续炎症反应-免疫抑制-分解代谢综合征(PICS)常发生于在ICU中早期经历了多脏器功能衰竭而抢救成功的危重患者。此类患者机体存在持续的炎症反应、免疫抑制和代谢紊乱,主要表现为残存的器官功能障碍、虚弱甚至恶液质,其免疫功能受损易反复发生院内感染、影响远期预后。本文主要就PICS的发病机制、危险因素及治疗进展进行综述,以期为PICS的防治提供新的思路。

Persistent inflammation-immunosuppression-catabolism syndrome(PICS)often occurs in critically ill patients who have experienced multiple organ failure in the early stage of ICU and have been rescued successfully.There are persistent inflammatory response,immunosuppression and metabolic disorder in the body,mainly manifested as residual organ dysfunction,weakness and even cachexia,immune function damage and prone to repeated nosocomial infection,therefore,long term prognosis was affected.This article reviews the pathogenesis,risk factors and treatment progress of PICS,in order to provide new ideas for the prevention and treatment of PICS.