经动脉灌注化疗与常规SOX方案化疗对中晚期胃癌的临床疗效比较

Clinical Comparative Study of Transarterial Infusion Chemotherapy and Routine SOX Regimen Chemotherapy in the Treatment of Advanced Gastric Cancer

目的比较经动脉灌注化疗与常规替吉奥联合奥沙利铂(SOX)方案化疗治疗中晚期胃癌的临床疗效。方法回顾性分析91例中晚期胃癌患者的临床资料,均于治疗后进行了2年的随访,根据化疗方法的不同将其分为经动脉灌注化疗组(47例)和SOX组(44例),均治疗6个疗程,比较两组治疗前后免疫功能指标及肠道菌群数量,并统计两组治疗疗效、化疗毒副作用发生情况及治疗后1年、2年生存情况。结果经动脉灌注化疗组疾病缓解率高于SOX组(P<0.05);经动脉灌注化疗组治疗后Treg、Th17及Th17/Treg值低于SOX组(P<0.05);经动脉灌注化疗组治疗后双歧杆菌数量少于SOX组,大肠杆菌、肠球菌数量多于SOX组(P<0.05);经动脉灌注化疗组白细胞减少症严重程度轻于SOX组(P<0.05);经动脉灌注化疗组1年生存率及2年生存率均高于SOX组(P<0.05),经动脉灌注化疗组中位生存时间为19.2个月,SOX组中位生存时间为11.3个月。结论相比于常规SOX方案,采用经动脉灌注化疗治疗中晚期胃癌的疗效更佳,可提高生存率,并对免疫功能的影响较小,可改善肠道菌群失调。

Objective To compare the clinical curative effect of transarterial infusion chemotherapy and routine S-l combined with oxaliplatin(SOX)chemotherapy on advanced gastric cancer.Methods The clinical data of 91 patients with advanced gastric cancer were retrospectively analyzed.All patients were followed up for 2 years after treatment.According to different chemotherapy methods,they were divided into transarterial infusion chemotherapy group(47 cases)and SOX group(44 cases).Both groups were treated for 6 courses.The immune function indexes and the number of intestinal floras before and after treatment were compared between the 2 groups.The curative effect,occurrence of chemotherapy side effects,and survival status at 1 year and 2 years after treatment in both groups were statistically analyzed.Results The disease remission rate in transarterial infusion chemotherapy group was higher than that in SOX group(P<0.05).After treatment,Treg,Th17 and Th17/Treg in transarterial infusion chemotherapy group were lower than those in SOX group(P<0.05),number of Bifidobacteria was less than that in SOX group,and number of Escherichia coli and Enterococci was more than that in SOX group(P<0.05).The severity of leukopenia in intraarterial infusion chemotherapy group was milder than that in SOX group(P<0.05),1-year and 2-year survival rates were higher than those in SOX group(P<0.05).The median survival time in transarterial infusion chemotherapy group and SOX group was 19.2 months and 11.3 months,respectively.Conclusion Compared with routine SOX regimen,the curative effect of intraarterial infusion chemotherapy is better on advanced gastric cancer,which can increase survival rate,with fewer effects on immune function.And it can improve the intestinal flora imbalance.