中医药治疗干燥综合征的作用机制研究进展

Mechanism of Chinese Medicine Against Sj?gren Syndrome:A Review

干燥综合征是一种慢性自身免疫性疾病,以免疫细胞浸润,唾液腺和泪腺的进行性损伤为主要特征,除了影响泪腺和唾液腺,导致眼睛干涩和口干症状外,还会累及人体心、肺、肾和中枢神经等多个系统,严重影响人体身心健康。虽然近年来西医在该病的诊断和治疗方面有了广泛和深入的研究,但目前还没有针对潜在病因的治疗方法。中医药在整体观的基础上,能够辨证施治,随证遣方,具有多靶点、多层次、多途径的治疗特点。目前随着中医药现代化研究的进展,发现其在治疗本病方面有着独特的优势,在调节免疫、降低炎症反应及上调水通道蛋白等方面有着姣好的作用,既能缓解临床症状,延缓病情,又能够减轻激素等药物的不良反应。通过回顾近年来关于中医药治疗干燥综合征(SS)的相关文献,对其发病机制及中医药作用的相关机理做了进一步的总结,本文拟从调节免疫、上调水通道蛋白及抗氧化应激等方面就中医药治疗本病的相关机制做一研究归纳,以期为相关实验研究及临床提供更多的理论依据。

Sj?gren syndrome(SS)is a chronic autoimmune disease characterized by immune cell infiltration and progressive destruction of salivary and lacrimal glands. It not only affects the lacrimal and salivary glands,manifested as dry eyes and dry mouth,but also involves heart,lung,kidney,and central nervous system,seriously affecting human physical and mental health. Although western medicine has made extensive and in-depth research on the diagnosis and treatment of this disease in recent years,there is no effective treatment targeting the potential causes. Chinese medicine emphasizes the concept of holism,treatment and prescription formulation based on syndrome differentiation,and effect exertion via multiple targets,multiple levels,and multiple pathways,exhibiting great advantages in the treatment of SS. This paper reviews the mechanisms of Chinese medicine in treating SS from the perspectives of immunity regulation,aquaporin upregulation,and anti-oxidative stress reported in the related literature,so as to provide more theoretical basis for the research and clinical treatment of SS.