恶性肿瘤患者不良心理状况调查及其影响因素分析

Factors Influencing Poor Psychological Status in Patients with Malignant Tumors

目的:通过调查初诊恶性肿瘤患者焦虑、抑郁和睡眠质量状况,了解肿瘤患者患病初期焦虑、抑郁等相关情绪障碍的发生情况,以及对机体免疫的影响,探讨可能影响患者焦虑、抑郁、睡眠质量的相关因素。方法:选取106例恶性肿瘤初诊患者,采用汉密顿焦虑量表(Hamilton Rating Scale for Anxiety,HAM-A)、汉密顿抑郁量表(Hamilton Rating Scale for Depression,HAM-D)及匹茨堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI),分别对患者焦虑、抑郁、睡眠质量状况进行初步筛查,并收集患者一般信息,以分析其可能的影响因素。结果:106例初诊患者中存在抑郁情绪29例(27.4%);焦虑情绪63例(59.4%),睡眠质量较差(PSQI评分身5)94例(占88.7%)。相关性分析提示HAM-A与HAM-D、HAM-D与PSQI呈正相关关系,且关系密切(P>0.5);而HAM-A与PSQI呈正相关关系,但关系并不密切。在影响因素上职业类型为焦虑状态发生的影响因素;且焦虑患者的CD3+CD4+T/CD3+CD8+T比值较无焦虑患者更低(P<0.05)。教育程度则是影响抑郁发生的危险因素(P<0.05),但与年龄、性别、职业、生育状况、肿瘤类型等因素不相关(P>0.05)。此外肿瘤患者抑郁状态对IgA有所影响(P><0.05)。结论:焦虑、抑郁情绪及睡眠障碍在初诊肿瘤患者中发生率较高。

Objective:To explore and analyze factors that may affect the occurrence of anxiety,depression and other psychological disorders in patients with malignant tumors,as well as their impacts on immunity,by investigating anxiety,depression and sleep quality of newly diagnosed patients with malignant tumors.Methods:A total of 106 patients with newly diagnosed malignant tumors were selected.Hamilton Rating Scale for Anxiety(HAM-A),Hamilton Rating Scale for Depression(HAM-D)and Pittsburgh Sleep Quality Index(PSQI)were used to conduct the Initial screening for anxiety,depression and sleep quality of patients.General information of patients was collected to analyze possible influence factors.Results:Of 106 patients,there were 29 cases(27.4%)of depression,63 cases(59.4%)of anxiety and 94 cases(88.7%)of poor sleep quality.Pearson correlation coefficients showed strong positive correlations between HAM-A and HAM-D,between HAM-D and PSQI(r>0.5),as well as a slight positive correlation between HAM-A and PSQI.Among them,labor type were the influence factors of anxiety;CD3+CD4+T/CD3+CD8+T of patients with anxiety was lower than that of patients without anxiety(P<0.05).Education was a risk factor of depression(P<0.05)which was not related to other factors such as age,gender,occupation,parity and tumor type(P>0.05).In addition,depression in cancer patients had an effect on immunoglobulin(P<0.05).Conclusion:The incidences of anxiety and depression in cancer patients are high.