杨素清教授治疗寻常型银屑病血瘀证的药对研究

Analysis of herbs-combination of Professor Yang Su-qing in the treatment of psoriasis vulgaris with blood stasis syndrome

目的:挖掘杨素清教授治疗寻常型银屑病血瘀证的用药经验并分析其组方特点。方法:筛选杨素清教授治疗寻常型银屑病血瘀证的临床门诊处方提取中药并进行标准化处理分析。结果:通过分析药物关联规则以及药物组合研究,总计提取中药149味,其中常用中药前12位,出现频次>30,频次出现最高的为甘草,防风,荆芥,当归,白芍,川芎,熟地黄,蝉蜕,牡蛎,龙骨。防风、甘草、荆芥、当归、白芍以上五味为杨素清教授在治疗寻常型银屑病血瘀证的最常用中药组合。结论:根据分析发现,组方中除治疗血瘀证首选的活血化瘀药外,运用防风、荆芥等祛风达表药,协同发挥活血祛瘀、祛风达表之功,疗效显著。

Objective:To explore Professor Yang Su-qing's experience in treating blood stasis syndrome of psoriasis vulgaris and analyze the characteristics of its prescription.Methods:Outpatient prescriptions for the treatment of psoriasis vulgaris with blood stasis syndrome were selected and traditional Chinese medicine was extracted for standardized processing.Then the data were analyzed by using set visualization analysis and Apriori algorithm.Results:A total of 149 traditional Chinese herbs were extracted.Among them,the top 12 commonly used herbs with frequency>30 were Licorice,Saposhnikovia,Schizonepeta tenuifolia,Angelica sinensis,Paeonia lactiflora,Ligusticum chuanxiong,Rehmannia glutinosa,Cicada slough,Oyster and Keel through the set visualization analysis,herbs association rules analysis,and herbs combination analysis.Saposhnikovia,Liquorice,Schizonepeta tenuifolia,Angelica sinensis and Paeonia Alba are the most commonly used combination of herbs by Professor Yang Su-qing in the treatment of blood stasis syndrome of psoriasis vulgaris.Conclusion:In addition to invigorating blood circulation and removing blood stasis herbs,which are preferred for the treatment of blood stasis syndromes,Saposhnikovia and Schizonepeta tenuifolia,etc.are used to synergistically exert the functions of invigorating blood circulation and removing blood stasis and eliminating wind expression,with remarkable efficacy.