不安腿综合征患者血清维生素D水平及相关因素分析

Analysis of serum vitamin D level and related factors in patients with restless legs syndrome

目的:检测原发性不安腿综合征(RLS)患者血清维生素D(VitD)水平,并分析VitD水平与RLS症状严重程度及睡眠、焦虑抑郁情绪的关系.方法:检测57例原发性RLS患者及同期的健康体检人群的血清25-羟维生素D[25(OH)D]水平,利用国际不安腿综合征严重程度评分量表(IRLSSG)、匹茨堡睡眠质量指数量表(PSQI)、汉密尔顿抑郁量表(24项版)(HAMD24)、汉密尔顿焦虑量表(14项版)(HAMA14)评估RLS患者的症状严重程度、睡眠、情绪状态,分别根据VitD水平、IRLSSG评分进行分组分析.结果:(1)RLS患者血清25(OH)D水平低于健康对照组,并且RLS患者血清VitD水平不足的发生率高于健康人群,差异具有统计学意义(均P<0.05).(2)(极)重度RLS患者血清VitD水平低于轻中度RLS患者,差异具有统计学意义(P<0.05).(3)RLS患者中血清VitD水平不足组患者IRLSSG评分及HAMD24评分高于血清VitD水平正常组,差异具有统计学意义(均P<0.05).(4)RLS患者IRLSSG量表评分与血清VitD水平及各量表分值之间的相关性分析显示,IRLSSG评分与VitD水平呈负相关,IRLSSG评分与PSQI、HAMA14、HAMD24评分呈正相关.(5)RLS患者血清VitD水平与各量表分值之间的相关性分析显示,血清VitD水平与IRLSSG量表评分、PSQI评分、HAMD24评分呈负相关.结论:RLS患者血清VitD水平普遍低于健康人群,且血清VitD水平越低,RLS症状越严重,睡眠质量越差,抑郁情绪越重.

Objective:To detect serum vitamin D(VitD)level in patients with primary restless legs syndrome(RLS)and analyze the relationship between VitD level and severity of RLS symptoms,sleep,anxiety and depression.Methods:The serum VitD levels of 57 patients with primary RLS and healthy people in the same period was detected.The severity of symptoms,sleep and emotional state of patients with RLS were evaluated by international restless legs syndrome rating scale(IRLSSG),Pittsburgh sleep quality index(PSQI),Hamilton depression scale 24 item(HAMD24)and Hamilton anxiety scale 14 item(HAMA14).According to VitD level and IRLSSG score,group analysis was performed.Results:(1)The serum VitD level in patients with RLS was lower than that in healthy control group.The incidence of insufficient serum VitD level in patients with RLS was significantly higher than that in healthy people,the difference was statistically significant(P<0.05).(2)The serum VitD level in patients with(extremely)severe RLS was significantly lower than that in patients with mild and moderate RLS,and the difference was statistically significant(P<0.05).(3)The IRLSSG score and the HAMD24 score of patients with insufficient serum VitD level in RLS were higher than those of patients with normal serum VitD level,the difference was statistically significant(P<0.05).(4)The correlation analysis between the IRLSSG score and the serum VitD level and each scale score in patients with RLS showed that the IRLSSG score was negatively correlated with the VitD level,while the IRLSSG score was positively correlated with the PSQI score,the HAMA14score and the HAMD24 score.(5)The Correlation analysis between the serum VitD level and the scores of various scales in patients with RLS showed that the serum VitD level was negatively correlated with the IRLSSG score,the PSQI score and the HAMD24 score.Conclusion:The serum VitD level of patients with RLS is generally lower than that of healthy people,and the lower the serum VitD level,the more serious the symptoms of RLS,the worse the sleep quality and the more severe the depression state.