注射用阿莫西林钠克拉维酸钾联合二羟丙茶碱治疗慢性支气管炎急性发作期的临床效果

Clinical Effect of Amoxicillin Sodium and Clavulanate Potassium for Injection Combined with Dihyprophylline in the Treatment of Acute Exacerbation of Chronic Bronchitis

目的探讨注射用阿莫西林钠克拉维酸钾联合二羟丙茶碱治疗慢性支气管炎急性发作期的临床效果。方法选取2018年6月至2021年6月于河南省人民医院豫东分院就诊的80例慢性支气管炎急性发作期患者。依据随机数字表法将患者分为对照组和观察组,各40例。所有患者接受常规治疗。在此基础上,给予对照组注射用阿莫西林钠克拉维酸钾治疗,给予观察组注射用阿莫西林钠克拉维酸钾联合二羟丙茶碱治疗,持续治疗14 d。比较两组临床症状缓解时间、不良反应发生率。于治疗前、治疗14 d时比较两组肺功能,包括用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/FVC。比较两组治疗前、治疗14 d炎症因子水平,包括肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)。结果与对照组比较,观察组肺部啰音、喘息、咳嗽以及咳痰消失时间均较短(P<0.05)。治疗14 d,两组FVC、FEV_(1)、FEV_(1)/FVC水平均高于治疗前,观察组FVC、FEV_(1)、FEV_(1)/FVC水平高于对照组(P<0.05)。治疗14 d,两组血清TNF-α、IL-6及CRP水平低于治疗前,观察组血清TNF-α、IL-6及CRP水平低于对照组(P<0.05)。观察组不良反应总发生率与对照组比较,差异无统计学意义(P>0.05)。结论注射用阿莫西林钠克拉维酸钾联合二羟丙茶碱治疗急性发作期慢性支气管炎患者的效果较好,可缩短症状消失时间,增强肺功能,降低炎症因子水平。

Objective To investigate the clinical effect of amoxicillin sodium and clavulanate potassium for injection combined with dihyprophylline in the treatment of acute exacerbation of chronic bronchitis.Methods A total of 80 patients with acute exacerbation of chronic bronchitis who were treated in East Henan Branch of Henan Provincial People’s Hospital from June 2018 to June 2021 were selected.According to the random number table method,the patients were divided into control group and observation group,each with 40 cases.All patients received conventional treatment.On this basis,the control group was given amoxicillin sodium and clavulanate potassium for injection,and the observation group was given amoxicillin sodium and clavulanate potassium for injection combined with dihyprophylline,and the treatment was continued for 14 days.The clinical symptom relief time and the incidence of adverse reactions were compared between the two groups.The lung functions of the two groups were compared before treatment and 14 days after treatment,including forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1))and FEV_(1)/FVC.The levels of inflammatory factors,including tumor necrosis factor-α(TNF-α),C reactive protein(CRP)and interleukin-6(IL-6)were compared before and 14 days after treatment between the two groups.Results Compared with the indicators in control group,the disappearance time of lung rales,wheezing,coughing and expectoration in observation group was shorter(P<0.05).After 14 days of treatment,the levels of FVC,FEV_(1) and FEV_(1)/FVC in the two groups were higher than those before treatment,and the levels of FVC,FEV_(1),FEV_(1)/FVC in observation group were higher than those in control group(P<0.05).On the 14th day of treatment,the levels of serum TNF-α,IL-6 and CRP in the two groups were lower than those before treatment,and the levels of serum TNF-α,IL-6 and CRP in observation group were lower than those in control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between observation group and control group(P>0.05).Conclusion Amoxicillin sodium and clavulanate potassium for injection combined with dihyprophylline are effective in the treatment of patients with chronic bronchitis in acute exacerbation.It could shorten the time of symptom disappearance,enhance lung function and reduce the level of inflammatory factors.