益生菌和粪菌移植调节炎症性肠病的研究进展

Progress in Understanding the Role of Probiotics and Fecal Microbiota Transplantation in Regulating Inflammatory Bowel Disease

炎症性肠病(inflammatory bowel diseases,IBD)是一种易复发的慢性胃肠道炎症性疾病,近年来在世界范围内的发病率逐渐上升。IBD的发病因素复杂,主要是由遗传、环境、免疫等因素相互作用导致的,随着宿主-肠道微生物相互作用的深入研究,人们发现肠道菌群在IBD的进展中发挥着重要作用,因此基于调节肠道微生物群缓解或治疗IBD的新型方法也备受关注。近年来的大量研究都表明益生菌、粪菌移植可以通过调节肠道微生物的组成、增强肠道屏障功能、调节机体免疫反应等达到缓解IBD的目的。因此,本文对IBD的发病因素以及益生菌、粪菌移植调节IBD的研究进展进行综述。

Inflammatory bowel disease(IBD)is a chronic and recurrent gastrointestinal inflammatory disease,whose incidence is increasing worldwide in recent years.Its pathogenesis is complicated,which is mainly caused by the interaction of genetic,environmental and immune factors.Intensive studies of the host-gut microbial interaction have demonstrated that the intestinal microflora plays an important role in the development of IBD.Therefore,there is tremendous interest in developing new methods to relieve and treat IBD by regulating the gut microbiota.In recent years,a large number of studies have proved that probiotics and fecal microbiota transplantation(FMT)may alleviate IBD by regulating the composition of intestinal microflora,enhancing the mucosal barrier function and regulating the immune response.This article reviews the recent progress in the pathogenesis of IBD and the application of probiotics and fecal bacteria transplantation on IBD.