挽救性淋巴结清扫术在前列腺癌根治性治疗后淋巴结复发患者中的应用进展

Research progress of salvage lymph node dissection in advanced prostate cancer

根治性前列腺切除术是治疗局限性前列腺癌的金标准,但术后生化复发率可达到20%~50%。在某些情况下,挽救性淋巴结清扫术(SLND)可改善肿瘤控制并延迟全身治疗。本文总结目前适合行SLND的患者选择、SLND术式的探索以及SLND的安全性和肿瘤控制效果。尽管目前仍缺乏支持SLND的前瞻性研究证据,但是术前成像技术的进步以及微创手术的广泛使用,使SLND显示出较好的肿瘤控制效果,但仍需大规模、标准化的临床试验进一步验证SLND的有效性和安全性。

Prostate cancer(PCa)is one of the most common invasive cancers in men.Radical prostatectomy is the gold standard for localized prostate cancer,but the postoperative biochemical recurrence rate can reach 20%-50%.In some cases,salvage lymph node dissections(SLND)seem to improve cancer control and delay systemic treatment.In this article,we review the current state of diagnostic imaging,accurate patient selection criteria,exploration of SLND surgical procedures,as well as the safety and tumor outcomes of SLND.Overall,although there is still a lack of strong prospective evidence to support the role of SLND,advances in preoperative imaging techniques and the widespread use of minimally invasive surgery have led to encouraging tumor outcomes with SLND.However,further large-scale and high quality trials are needed to confirm the effectiveness and safety of SLND.