沙库巴曲缬沙坦对心衰患者心室重构及血清TNF-α、IL-33及ICAM-1水平的影响

Effects of sacubitril valsartan on ventricular remodeling and serum levels of TNF-α,IL-33 and ICAM-1 in patients with heart failure

目的:分析沙库巴曲缬沙坦对心衰患者心室重构及血清TNF-α、IL-33及ICAM-1水平的影响。方法:将61例心衰患者按随机数表方法分为对照组(n=30)和观察组(n=31)。对照组采取常规抗心衰药物治疗,观察组采用沙库巴曲缬沙坦治疗。治疗4周后,对比两组心室重构情况及血清TNF-α、IL-33及ICAM-1水平。结果:观察组治疗后IVST、LVPWT水平低于对照组,LVMI水平高于对照组(P<0.05);血清TNF-α、IL-33及ICAM-1水平均低于对照组(P<0.05)。结论:沙库巴曲缬沙坦能够降低心衰患者血清TNF-α、IL-33及ICAM-1水平,阻碍心脏重构。

Objective:To investigate the effects of sacubitril valsartan on ventricular remodeling and serum levels of TNF-a,IL-33 and intercellular cell adhesion molecule-1(ICAM-1)in patients with heart failure.Methods:Sixty-one patients with heart failure were randomly divided into a control group(n=30)and an observation group(n=31).The control group was treated with routine anti-heart failure drugs,and the observation group was treated with sacubitril valsartan.Ventricular remodeling and serum levels of TNF-a,IL-33 and ICAM-1 were compared between the two groups four weeks after treatment.Results:After treatment,the levels of interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),serum TNF-a,IL-33 and ICAM-1 were lower while the levels of left ventricular mass index(LVMI)were higher in the observation group than the control group(P<0.05).Conclusion:Sacubitril valsartan can decrease serum levels of TNF-a,IL-33 and ICAM-1 in the patients and block cardiac remodeling.