秋水仙碱治疗新型冠状病毒肺炎研究

Colchicine in the treatment of coronavirus disease 2019

新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)仍在全球肆虐,对其患者除对症处理外,没有有效的治疗措施。目前,COVID-19治疗以抗病毒治疗为主,酌情给予抗炎治疗,但除糖皮质激素外,其他抗炎药物的使用并无明确的依据。秋水仙碱是临床上常用的抗炎药物之一,有研究发现它治疗COVID-19有效,现正在进行多项临床研究。本文介绍秋水仙碱治疗COVID-19有效的可能机制和相关临床研究情况。

Coronavirus disease 2019(COVID-19)is still raging around the world and there is no effective therapy for its patients except for the symptomatic treatment.At present,the treatment of COVID-19 is based on antiviral therapy and antiinflammatory treatment is given as appropriate.However,there is no clear basis for the use of other anti-inflammatory drugs except for glucocorticoids.Colchicine is one of the anti-inflammatory drugs commonly used in clinic,studies have found that it is effective in the treatment of COVID-19 and a number of clinical trials are currently underway.This article introduces the possible mechanisms of colchicine for the effective treatment of COVID-19 and the related clinical research status.