急性有机磷中毒致心律失常的相关因素及预后探讨

Correlative factors and prognosis of arrhythmia caused by acute organophosphate poisoning

目的探讨急性有机磷中毒(acute organophosphate poisoning,AOPP)致心律失常的相关因素及预后。方法对2019年1月-2020年9月国药东风总医院收治的352例AOPP患者的临床资料进行回顾性分析,分析AOPP致心律失常患者特点,对影响AOPP合并心律失常患者预后的因素进行分析。结果AOPP致心律失常组与AOPP未合并心律失常组在合并高血压、合并糖尿病、合并高脂血症、空腹服毒、抬头困难、白细胞计数方面对比差异具有统计学意义(P<0.05);单因素与多因素分析显示就诊时间、洗胃时间、血液灌流、急性生理学与慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分为影响AOPP合并心律失常患者预后的相关因素(OR值分别为2.042、2.713、1.941、2.330,95%CI值分别为1.847~4.389、2.021~8.001、1.754~3.987、2.014~5.127,均P<0.05)。结论在AOPP患者诊治中注意上述影响因素,尽早规避或预防。

Objective To explore the related factors and prognosis of arrhythmia caused by acute organophosphate poisoning(AOPP).Methods The clinical data of 352 AOPP patients admitted to our hospital from January 2019 to September 2020 were retrospectively analyzed.The characteristics of patients with arrhythmia caused by AOPP were analyzed,and the factors affecting the prognosis of AOPP patients with arrhythmia were analyzed.Results There were statistically significant differences between the AOPP-induced arrhythmia group and the AOPP group without arrhythmia in terms of hypertension,diabetes,hyperlipidemia,fasting poisoning,difficulty raising the head,and white blood cell count(P<0.05).Univariate and multivariate analysis showed that visit time,gastric lavage time,blood perfusion,Acute Physiology and Chronic Health Status Score System II(APACHE II)scores were factors affecting the prognosis of patients with AOPP and arrhythmia(OR values were 2.042,2.713,1.941,2.330;95%CI were 1.847~4.389,2.021~8.001,1.754~3.987,2.014~5.127,all P<0.05).Conclusion Pay attention to the above influencing factors in the diagnosis and treatment of AOPP patients,and avoid or prevent them as soon as possible.