影响社区稳定期精神分裂症患者认知功能的相关因素分析

Analysis of related factors affecting the cognitive function of patients with stable schizophrenia in the community

目的探索影响社区稳定期精神分裂症患者认知功能的相关因素。方法采用修订版韦氏成人智力分量表数字广度、数字符号、语言流畅性、连线测验A评估78例社区稳定期精神分裂症患者认知功能,家庭负担量表(FBS)、用药依从性问卷(MMAS)评定家庭负担、服药依从性,分析认知功能与有关资料的相关性。结果受教育年限与数字广度、语言流畅性正相关(r=0.562、0.525,P=0.019、0.018),家庭月收入与数字符号正相关(r=0.601,P=0.005),二者与连线测验A负相关(r=-0.565、-0.519,P=0.010、0.019);吸烟与数字符号正相关(r=0.518,P=0.019);饮酒与语言流畅性正相关(r=0.465,P=0.039)。FBS得分与MMAS得分负相关(r=-0.346,P<0.001),数字广度、数字符号、语言流畅性、连线测验A与FBS得分负相关(r=-0.254、-0.243、-0.350、0.188,P=0.003、0.004、0.000、0.029),与MMAS得分正相关(r=0.254、0.325、0.339,P=0.003、0.000、0.000)。受教育年限、吸烟、饮酒进入各因变量回归方程,差异有统计学意义(P<0.05)。结论受教育年限、家庭月收入、吸烟、饮酒、家庭负担、服药依从性是影响社区稳定期精神分裂症患者认知功能的因素。

Objective To explore the related factors influencing the cognitive function of the patients with stable schizophrenic in the community.Methods The cognitive function of 78 patients with stable schizophrenic in the community was evaluated by the digit span,digit symbols,language fluency and connection test of A of the Wechsler Adult Intelligence Scale.The Family Burden Scale Disease(FBS)and Morisky Medication Adherence Scale(MMAS)were used to assess family burden and medication compliance respectively,and analyzed the correlation between cognitive function and relevant data.Results Years of education was positively correlated with the digit span and the language fluency(r=0.562,0.525;P=0.019,0.018).The monthly household income was positively correlated with the digit symbols(r=0.601,P=0.005),and they were negatively correlated with the connectivity test A(r=-0.565,-0.519;P=0.010,0.019).Smoking was positively correlated with the digit symbols(r=0.518,P=0.019);the alcohol consumption was positively correlated with the language fluency(r=0.465,P=0.039).The FBS score was negatively correlated with the MMAS score(r=-0.346,P<0.001);the digit span,digit symbols,language fluency and connectivity test A were negatively correlated with the FBS scores(r=-0.254,-0.243,-0.350,0.188;P=0.003,0.004,0.000,0.029),and positively correlated with the MMAS score(r=0.254,0.325,0.339;P=0.003,0.000,0.000).Years of education,smoking and alcohol consumption entered the regression equation of each dependent variable,and the differences were statistically significant(P<0.05).Conclusion Years of education,family monthly income,smoking,alcohol consumption,family burden,and medication compliance were relatedfactors affecting the cognitive function of patients with stable schizophrenic in the community.