2型糖尿病患者并发症数目与焦虑障碍的相关研究

A study on the relationship between the number of complications and anxiety disorders in patients with type 2 diabetes

目的探究2型糖尿病(T2DM)患者并发症数目与焦虑障碍的相关性。方法选取2018年9月至2019年10月于陕西省人民医院心血管疾病内一科住院治疗的295例T2DM患者,采用汉密尔顿焦虑量表(HAMA)对其进行焦虑障碍评估,并分析相关临床资料。结果无并发症患者HAMA评分(5.06±2.10)分、合并1个并发症(8.24±3.66)分、合并2个并发症(12.93±3.54)分、合并3个并发症(16.88±4.60)分、合并4个并发症(18.50±2.66)分,组间比较差异有统计学意义(P<0.001)。Pearson相关性分析显示:HAMA评分与年龄(r=0.250,P<0.001)、糖尿病病程(r=0.431,P<0.001)、每天注射胰岛素次数(r=0.255,P<0.001)、血红蛋白(HB,r=-0.209,P<0.001)、总胆固醇(TC,r=0.134,P=0.021)、肌酐(Cr,r=0.230,P<0.001)呈线性相关;Logistic回归分析显示在校正年龄、糖尿病病程、高血压、HB、Cr、是否使用胰岛素、聚居地、有无使用降糖药、每天注射胰岛素次数后,T2DM患者TC(OR=1.675,P=0.005)、B型钠尿肽(BNP,OR=1.013,P=0.045)、糖尿病并发症数目(OR=5.021,P<0.001)与HAMA评分相关。结论T2DM患者并发症数目、总胆固醇及BNP均可增加T2DM患者焦虑发生的危险性,其中糖尿病并发症数目对焦虑发生的影响力更大。

Objective To explore the correlation between the number of complications and anxiety disorders in patients with type 2 diabetes mellitus(T2DM).Methods A total of 295 T2DM patients hospitalized in the First Department of Cardiology of the Shaanxi Provincial People′s Hospital were selected from September 2018 to October 2019.The Hamilton Anxiety Scale(HAMA)was used to assess their anxiety disorders and the relevant clinical data were analyzed.Results There were statistically significant differences in the HAMA scores among patients without diabetic complications[(5.06±2.10)points],with one complication[(8.24±3.66)points],with two complications[(12.93±3.54)points],with three complications[(16.88±4.60)points]and with four complications[(18.50±2.66)points],P<0.001.The Pearson correlation analysis showed that HAMA score was linearly correlated with age(r=0.250,P<0.001),course of diabetes mellitus(r=0.431,P<0.001),times of daily insulin injection(r=0.255,P<0.001),hemoglobin(HB,r=-0.209,P<0.001),total cholesterol(TC,r=0.134,P=0.021),and creatinine(CR,r=0.230,P<0.001).The logistic regression analysis showed that TC(OR=1.675,P=0.005),brain natriuretic peptide(BNP,OR=1.013,P=0.045),number of diabetic complications(OR=5.021,P<0.001)were related to the scores of HAMA in T2DM patients after adjusting for age,course of disease,hypertension,HB,CR,insulin use,settlement,hypoglycemic drugs use,and times of daily insulin injection.Conclusion The number of diabetic complications,total cholesterol and BNP can increase the risk of anxiety in T2DM patients,and the number of diabetic complications has a bigger impact on anxiety.