从趋化因子调节疼痛视角探讨针刺镇痛新机制

New Mechanism of Acupuncture Analgesia in Terms of Chemokines Regulating Pain

疼痛是涉及到感觉、情感和认知等多个方面的一种痛苦体验,严重影响患者的身心健康。近年来,趋化因子调节疼痛作用的研究受到高度关注,趋化因子及其受体在外周或中枢通过激活神经元、胶质细胞和募集免疫细胞等方式参与疼痛调节作用。针刺镇痛优势显著,一直是针刺领域研究的热点,随着研究的不断深入,针刺镇痛机制处于不断更新之中;趋化因子介导针刺镇痛作用属于针刺镇痛新思路,在完善针刺镇痛机制中发挥重要作用。本研究通过对趋化因子及其受体参与疼痛调节的作用机制及其介导针刺镇痛作用机制现有文献进行综述,在此基础上提出趋化因子参与针刺镇痛这一新机制。

Pain is an awful experience involving sensation,emotion,cognition and other aspects,which seriously affects the physical and mental health of the patients.In recent years,much attention has been paid to the effect of chemokines on pain regulation.Chemokines and their receptors are involved in pain regulation by activating neurons,glial cells,recruiting immune cells and so on.Acupuncture analgesia has significant advantages,which has always been a hot spot in the field of acupuncture research.with the deepening of researches,the mechanism of acupuncture analgesia is constantly updated;chemokine-mediated acupuncture analgesia belongs to a new idea of acupuncture analgesia,which plays an important role in improving the mechanism of acupuncture analgesia.This study reviewed the existing literature on the mechanism of chemokines and their receptors involved in pain regulation and the mechanism of acupuncture analgesia mediated by chemokines and their receptors,and put forward a new mechanism of chemokines participating in acupuncture analgesia.