病原微生物防控在实验动物设施管理与生物安全控制中的作用探讨

Prevention and Control of Pathogenic Microorganisms for the Management and Biosafety Control in Laboratory Animal Facilities

生物安全管理是实验动物设施管理的重要环节。随着我国生物医药研究快速发展,动物实验及实验动物设施建设需求不断增大。规范实验动物设施管理,保障实验动物从业人员安全,加强实验动物健康监测体系建设,是目前行业良性发展的必然需要。病原微生物控制是实验室生物安全管理的核心,是评价实验室良好运行及其规范管理的一个重要指标。动物实验室因涉及动物活体实验或病原微生物感染实验,其潜在的生物安全风险更大。病原微生物控制是降低职业暴露风险和减少实验室获得性感染的有效途径。笔者总结多年的实验动物设施管理及生物安全控制经验,从病原微生物防控角度分析实验动物设施管理中的生物安全控制关键环节和注意事项,为提升实验动物设施管理及生物安全控制水平提供参考。

Appropriate biosafety management is a critical component of the successful operation of laboratory animal facilities.Standardizing the management of laboratory animal facilities,protecting staff,and strengthening the construction of laboratory animal health monitoring system are inevitable needs for the benign development of the laboratory animal industry.The control of microbial pathogens is a core component of laboratory biosafety management,and it is an important index for the evaluation of laboratory operation and management.The potential biosafety risk of animal laboratories is high owing to the experimentations with live animals,or pathogenic microorganisms.The control of microbial pathogens is an effective measure to reduce the risk of occupational exposure and acquired infections in laboratories.This study discusses microbial pathogen control strategies in laboratory animal facilities for promoting laboratory animal facility management and biosafety control.