光动力疗法联合冷冻治疗尖锐湿疣的临床效果

Clinical effect of photodynamic therapy combined with liquid nitrogen freezing on the treatment of condyloma acuminatum

目的针对光动力疗法联合冷冻治疗尖锐湿疣的临床效果进行探讨与研究。方法100例成年尖锐湿疣患者采用数字表法随机分为两组,对照组采用光动力疗法,观察组采用光动力疗法联合液氮冷冻,对比治疗前后的总有效率、复发率、不良发生率、疣体清除率以及21种人类乳头瘤病毒(human papilloma virus,HPV)基因分布。结果观察组总有效率为96%,复发率为6%,不良反应发生率为10%;对照组总有效率为90%,复发率为26%,不良反应发生率为38%,治疗后,观察组疣体直径短于对照组,两组差异有统计学意义(P<0.05)。结论相对单一应用光动力疗法,光动力联合液氮冷冻治疗尖锐湿疣治疗效果显著,治疗有效率高、疣体清除率高,复发率及不良反应率低,值得在临床中推广。

Objective To discuss and study the clinical effect of photodynamic therapy combined with liquid nitrogen cryotherapy on the treatment of condyloma acuminatum.Methods Totally 100 adult patients with condyloma acuminatum were randomly divided into two groups.The control group was treated with photodynamic therapy,and the observation group was treated with photodynamic therapy combined with liquid nitrogen freezing.The total effective rate,recurrence rate,adverse incidence rate,and wart removal before and after treatment were compared.Rate and the distribution of 21 HPV genes.Results The total effective rate of the observation group was 96%,the recurrence rate was 6%,and the incidence of adverse reactions was 10%;the total effective rate of the control group was 90%,the recurrence rate was 26%,and the incidence of adverse reactions was 38%.After treatment,the diameter of warts in the observation group shorter than the control group,the difference between the two groups is statistically significant(P<0.05).Conclusion Compared with the single application of photodynamic therapy,photodynamic combined with liquid nitrogen cryotherapy has a significant effect on the treatment of condyloma acuminatum,with high treatment efficiency,high wart clearance rate,low recurrence rate and adverse reaction rate,and it is worthy of clinical promotion.