新型冠状病毒肺炎患者早期检验指标与疾病严重程度相关性研究

Study on correlation between early laboratory examination indicators and disease severity in COVID-19 patients

目的探讨新型冠状病毒肺炎(coronavirus disease 2019, COVID-19)患者发病早期检验指标与疾病严重程度的相关性。方法回顾性分析武汉火神山医院2020年2—3月收治的326例COVID-19确诊患者的临床资料,将其分为普通型组(184例)与重型组(142例),分析2组患者的血常规、CRP、肝功能、心肌损伤标志物等检验指标与疾病严重程度的相关性。结果 CRP(rs=0.429)与疾病严重程度呈正相关,淋巴细胞计数(rs=-0.439)、ALB(rs=-0.539)与疾病严重程度呈负相关(P均<0.05);WBC、ALT、AST、γ-谷氨酰转肽酶、CK、CK-MB等指标与疾病严重程度无明显相关性。结论 CRP、淋巴细胞计数、ALB水平可作为预测COVID-19患者疾病严重程度的指标,为临床诊疗工作提供参考。

Objective To explore the correlation between early laboratory examination indicators and disease severity in coronavirus disease 2019(COVID-19) patients. Methods The clinical data of 326 patients with confirmed COVID-19 who were admitted to Wuhan Huoshenshan Hospital from February to March in 2020 were analyzed retrospectively. The involved patients were divided into normal group(184 cases) and severe group(142 cases). The correlation between routine blood test, CRP, liver function, myocardial injury markers and disease severity was analyzed. Results CRP(rs=0.429) was positively correlated with disease severity, while lymphocyte count(rs=-0.439) and ALB(rs=-0.539) were negatively correlated with disease severity(P <0.05). WBC, ALT, AST, γ-glutamyl transpeptidase, CK, CK-MB and other indicators had no obvious correlation with the disease severity. Conclusions CRP, lymphocyte count and ALB levels can be used as indicators to predict the disease severity in patients with COVID-19, which provide reference for clinical diagnosis and treatment.