经密闭式吸痰管注入肺表面活性物质治疗新生儿呼吸窘迫综合征的效果观察

Efficacy of pulmonary surfactant injection through closed suction tube in neonatal respiratory distress syndrome

目的比较经密闭式吸痰管与头皮针针头刺入气管插管注入肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法90例有创通气NRDS患儿分别采用头皮针针头刺入气管插管(对照组)或密闭式吸痰管(试验组)注入PS,比较两组治疗效果、不良反应和并发症。结果试验组外周血氧饱和度、心率及氧分压均高于对照组(P<0.01)。两组不良反应和并发症差异无统计学意义(P>0.05)。结论应用密闭式吸痰管注入PS治疗早产儿NRDS安全有效。

Objective To compare the efficacy of pulmonary surfactant(PS)injection through closed suction tube and endotracheal intubation with scalp needle in neonatal respiratory distress syndrome(NRDS).Methods Ninety preterm infants with NRDS undergoing invasive ventilation received PS injection via closed suction tube(experimental group)or endotracheal intubation with scalp needle(control group).Clinical efficacy,adverse reactions and complications were compared between two groups.Results Peripheral blood oxygen saturation,oxygen pressure and heart rate were higher in experimental group than in control group(P<0.01).Adverse reactions and complications were comparable between two groups(P>0.05).Conclusion PS injection via closed suction tube is safe and effective for premature infants with NRDS.