中心静脉导管慢速输注奥沙利铂对外周神经毒性的影响

Effect of slow infusion of oxaliplatin via peripherally inserted central catheter on peripheral neurotoxicity

目的观察通过中心静脉导管(PICC)慢速输入奥沙利铂对患者外周神经毒性的影响。方法将82例用mFOLFOX6方案化疗胃癌、大肠癌患者分为实验组和对照组。实验组患者经PICC输注奥沙利铂,输注时间为5~6 h;对照组经外周静脉留置针输入奥沙利铂,输注时间为2~3 h。比较两组患者外周神经毒性程度和生活质量评分情况。结果实验组患者外周神经毒性程度低于对照组(P<0.01),生活质量评分高于对照组(P<0.01)。结论经PICC配合慢速度输注奥沙利铂可减轻神经毒性反应,提高患者化疗期间生活质量。

Objective To observe the effect of slow infusion of oxaliplatin via peripherally inserted central catheter(PICC)on peripheral neurotoxicity.Methods A total of 82 patients with gastric cancer or colorectal cancer that have received mFOLFOX6 chemotherapy regimens were divided into the Study Group(n=40)and the Control Group(n=42).The Study Group received oxaliplatin infusion via PICC for 5-6 h while the Control Group received oxaliplatin infusion via indwelling peripheral venous catheter for 2-3 h.The two groups were compared in terms of the peripheral neurotoxicity and quality of life score.Results The Study Group had the peripheral neurotoxicity less severe than the Control Group(P<0.01),but had the quality of life score higher than the Control Group(P<0.01).Conclusion Slow infusion of oxaliplatin via PICC can reduce the severity of peripheral neurotoxicity and improve the patients'quality of life during chemotherapy.