摘要
The microbiota plays essential roles in health and disease,in both the intestine and the extra-intestine.Dysbiosis of the gut microbiota causes dysfunction in the intestine,which leads to inflammatory,immune,and infectious diseases.Dysbiosis is also associated with dis-eases beyond the intestine via microbial translocation or metabolisms.The in situ breast mi-crobiome,which may be sourced from the gut through lactation and sexual contact,could be altered and cause breast diseases.In this review,we summarize the recent progress in under-standing the interactions among the gut microbiome,breast microbiome,and breast diseases.We discuss the intestinal microbiota,microbial metabolites,and roles of microbiota in immune system.We emphasize the novel roles and mechanisms of the microbiome(both in situ and gastrointestinal sourced)and bacterial products in the development and progression of breast cancer.The intestinal microbial translocation suggests that the gut microbiome is translocated to the skin and subsequently to the breast tissue.The gut bacterial translocation is also due to the increased intestinal permeability.The breast and intestinal microbiota are important fac-tors in maintaining healthy breasts.Micronutrition queuine(Q)is derived from a de novo syn-thesized metabolite in bacteria.All human cells use queuine and incorporate it into the wobble anticodon position of specific transfer RNAs.We have demonstrated that Q modifica-tion regulates genes critical in tight junctions and migration in human breast cancer cells and a breast tumor model.We further discuss the challenges and future perspectives that can move the field forward for prevention,diagnosis,and treatment of breast diseases.
基金
We would like to acknowledge the United States National Institute of Diabetes and Digestive and Kidney Diseases[grant numbers R01DK105118-01 and R01DK114126 to Jun Sun]
United States Department of Defense Congressionally Directed Medical Research Programs[grant number BC160450 to Jun Sun]
and the UIC Cancer Center funds to Jun Sun.