摘要
端粒与冠心病存在密切相关性。近年来发现,端粒磨损通过激活p53蛋白调节一系列分子变化,或可成为冠心病早期风险评估因子或治疗的新靶点。本文就在冠心病中端粒-p53的调节作用及分子机制进行综述。
Telomeres are closely related to coronary heart disease.Recent studies have shown that telomere attrition regulate a series of molecular changes by activating p53 protein,which may become a new target for early risk assessment or treatment of coronary heart disease.This article reviews regulation and molecular mechanism of telomeres-p53 in coronary heart disease.
作者
赵海静
刘琪
刘昱圻
程龙
陈韵岱
Zhao Haijing;Liu Qi;Liu Yuqi;Cheng Long;Chen Yundai(Chinese PLA Medical School,Beijing 100853,China;Department of Cardiology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Institute of Biotechnology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100071,China)
出处
《中国心血管杂志》
2021年第5期491-494,共4页
Chinese Journal of Cardiovascular Medicine
基金
北京市科技新星计划(Z191100001119020)。
关键词
端粒
端粒酶
P53
冠心病
Telomere
Telomerase
P53
Coronary heart disease
