辅助性T细胞17和调节性T细胞在抑郁症中的作用机制研究进展

Research progress in the mechanism of helper T cell 17 and regulatory T cell in depression

抑郁症是一种全球性的精神疾病,发病率逐年上升,疾病负担重且发病机制复杂。近年来,随着对抑郁症炎症假说研究的不断深入,学者们发现该疾病的发生发展与辅助性T细胞17(helper T cell 17,Th17)和调节性T细胞(regulatory T cell,Treg)介导的免疫失衡密切关联。而且,有关报道指出Th17和Treg均可受肠道菌群的调节,而肠道菌群可通过脑-肠轴机制参与抑郁症的发病过程。此外,在基础实验研究和临床治疗中发现,外周血中Th17和Treg的水平能够影响抗抑郁药的疗效。因此,该文结合肠道菌群的研究,对Th17和Treg在抑郁症发病机制和抗抑郁药治疗中作用的研究进展进行简要综述。

Depression is a global mental illness with increasing incidence,heavy disease burden and complicated pathogenesis.In recent years,based on the inflammatory hypothesis of depression,studies have demonstrated that the occurrence and development of the disease is closely related to the immune imbalance mediated by helper T cell 17(Th17)and regulatory T cell(Treg).Moreover,reports have shown that both Th17 and Treg can be regulated by gut microbiome which involves in the pathogenesis of depression through the brain-gut axis mechanism.In addition,basic and clinical researches reveal that the levels of Th17 and Treg in peripheral blood are capable of affecting the efficacy of antidepressants.Therefore,this article combines the studies of gut microbiome to briefly review the research progress in the effect of Th17 and Treg on the pathogenesis of depression and the treatment of antidepressants.