双气相定量CT诊断COPD与肺气肿指数相关性研究

Correlation between COPD and emphysema index measured by dual gas-phase quantitative CT

目的:分析双气相定量CT诊断COPD与肺气肿指数相关性。方法:在获取患者及家属同意后选取2020年2月——2021年1月在我院收治的慢性阻塞性肺疾病患者67例,为COPD组,另同期选取65例体检健康人员为健康对照组。均行常规CT扫描,呼气、吸气双气相CT扫描,详细记录结果。对比两种检测阳性、阴性预测值,诊断效能。定量分析肺部相对值,采用Preason相关性分析法分析与肺气肿指数的相关性。结果:健康对照组、COPD组患者双气相CT定量指标总体比较(P<0.05);进一步两两相比,健康对照组全肺、右肺、左肺密度差均高于COPD组,全肺、右肺、左肺密度比、容积比均低COPD组P<0.05)。双气相定量CT扫描阳性、阴性预测值及灵敏度、特异度、准确性均高于常规CT扫描(P<0.05)。以双气相CT定量指标进行相关性分析,结果显示全肺容积差、密度差,右肺容积差、密度差,左肺容积差、密度差与COPD患者肺气肿指数呈正相关;全肺容积比、密度比,右肺容积比、密度比,左肺容积比、密度比与COPD患者肺气肿指数呈负相关。结论:双气相CT定量诊断COPD诊断效能良好,同时可定量分析COPD患者肺气肿情况,并存在一定相关性,为临床诊断提供更加精确的数据指导,临床应用价值较高。

Objective:The correlation between the dual gas-phase quantitative CT diagnosis of COPD and the emphysema index was analyzed.Methods:After obtaining the consent of patients and family members,67 COPD patients who were admitted to our hospital from February 2020 to January 2021 were selected as the COPD group,and another 65 healthy persons who were examined during the same period were selected as the healthy control group.All underwent conventional CT scan,and expiratory and inspiratory dual gas-phase CT scan,and the results were recorded in detail.Diagnostic efficacy was evaluated by comparing the positive and negative predictive values of the two tests.The relative values in the lungs were quantitatively analyzed,and the correlation with the emphysema index was analyzed by preason's correlation analysis.Results:Comparison of CT quantitative indexes between healthy control group and COPD group(P<0.05);Further pairwise comparison showed that the density differences of whole lung,right lung and left lung in healthy control group were higher than those in COPD group,while the density ratio and volume ratio of whole lung,right lung and left lung were lower than those in COPD group(P<0.05).The positive and negative predictive values,sensitivity,specificity and accuracy of dual-phase quantitative CT scanning were higher than those of conventional CT scanning(P<0.05).The correlation analysis was carried out by double-phase CT quantitative indexes,and the results showed that the whole lung volume difference and density difference,the right lung volume difference and density difference,and the left lung volume difference and density difference were positively correlated with the emphysema index of COPD patients.Whole lung volume ratio and density ratio,right lung volume ratio and density ratio,left lung volume ratio and density ratio were negatively correlated with emphysema index in COPD patientsConclusion:The quantitative diagnosis of COPD with dual gas-phase CT has good diagnostic efficacy,at the same time,it can quantitatively analyze the situation of emphysema in patients with COPD,and there is a certain correlation,which provides more precise data guidance for clinical diagnosis,and has a high value of clinical application.