摘要
近5年来眼睑皮脂腺癌研究取得一系列成果。临床研究方面,明确了眼睑皮脂腺癌冰冻切缘控制显微手术的意义,提出了患者预后指标;在基础研究方面,描述了基因突变谱,揭示了3种相互独立的发病模式,以及提出了免疫及靶向治疗相关研究;我国眼肿瘤工作者也在眼睑皮脂腺癌研究方面树立了国际地位。本文对近5年国内外眼睑皮脂腺癌相关研究方面的主要成果进行总结分析,并展望治疗前景,为临床提供有益参考。
In recent 5 years,a series of studies have been made in the mechanism of onset of eyelid sebaceous carcinoma worldwide.In clinical research,the prognosis has made in predicting progression of patients with eyelid sebaceous carcinoma,and the significancy of frozen margin control in microsurgery was clarified.In field of basic research,from elucidation of mutational landscape to revelation of three independent pathogenesis patterns,from researches on immunotherapy to targeted therapy,efforts have been made to reveal the pathological mechanism to both aspect of its morbidity and development.This paper summarizes,analyzes and reviews the main achievements in recent 5 years on eyelid sebaceous carcinoma.
作者
许诗琼(综述)
贾仁兵(审校)
XU Shiqiong;JIA Renbing(Department of Ophthalmology,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology,Shanghai 200011,China)
出处
《眼科学报》
CAS
2021年第9期762-765,共4页
Eye Science
基金
国家自然科学基金(81802702)
上海市眼眶病眼重瘤重点实验室(17DZ2260100)
上海科学技术委员会项目(17JC1420100)。
关键词
眼睑皮脂腺癌
基因谱
切缘控制
靶向治疗
治疗共识
eyelid sebaceous carcinoma
mutational landscape
margin control
targeted therapy
treatment consensus
