非甾体抗炎药致血小板减少性紫癜文献分析

Literature Analysis of NSAIDs Lead to Thrombocytopenic Purpura

目的探讨非甾体抗炎药(NSAIDs)致血小板减少性紫癜的临床特点和危险因素,为临床合理用药提供参考。方法通过检索国内外期刊中关于非甾体抗炎药致血小板减少性紫癜的文献,并对服药情况、临床特点、机制研究等方面进行综合分析。结果共收集到病例23例,使用的非甾体抗炎药8种,连续用药>1周(10例),超剂量(2例)。男女比为1.55∶1。不同年龄段患者性别比例无统计学差异(P>0.05)。综合分析临床表现、实验室检查、骨髓检查等。患者经治疗后PLT显著上升,有显著性差异(P<0.05)。病死率8.70%。结论NSAIDs引起的血小板减少性紫癜病死率较高。应加强宣传教育,重在预防,引导患者正确使用药物。

Objective To investigate the clinical features and risk factors of nonsteroidal antiinflammatory drugs to thrombocytopenic purpura(TP),in order to provide references for its clinical rational application.Methods The related literatures of TP caused by NSAIDs was retrieved,and drug administration,clinical characteristics and mechanism were analyzed comprehensively.Results The clinical data of 23 cases were collected,8 types of NSAIDs were used,including continuous use over 1 week(10 cases)and overdose(2 cases).Male and female ratio was 1.55∶1.There was no statistically significant difference in the sex ratio between people of different ages.Comprehensive analysis of clinical manifestation,laboratory examination,bone marrow examination diagnosis was made for diagnosis.PLT was significantly increased after the treatment,and it was significant difference(P<0.05).Mortality was 8.70%.Conclusion The fatality rate of thrombocytopenic purpura caused by NSAIDs was higher,which should be strengthen the propaganda education.The emphasis was prevention,and to guide the patients right use of drugs.