高三酰甘油-腰围表型与高尿酸血症的关联性

The association between hypertriglyceridemia-waist and hyperuricemia

目的研究高三酰甘油-腰围(hypertriglyceridemia-waist,HTGW)表型与高尿酸血症(hyperuricemia,HUA)的关系,为早期识别HUA的高危个体提供依据。方法采用多阶段抽样的方法抽取中山市24个镇区的成人进行现场问卷调查、体格检查及生化指标检测。使用Logistic回归分析模型、Goodman-Kruskal法和多元线性逐步回归分析HTGW表型与HUA之间的关系。结果共纳入研究对象7173人,HTGW表型人群共1089人,检出率为15.2%,HUA患者共2332人,检出率为32.5%。多因素Logistic回归分析模型分析结果显示HTGW表型为HUA患病的重要危险因素(OR=2.689,95%CI:2.249~3.215,P<0.001)。Goodman-Kruskal法关联性分析和多元线性回归模型均显示HTGW表型与HUA存在着明显的正相关关系(P<0.001)。结论HTGW表型为HUA患病的重要危险因素,在日常防治HUA的过程中,应重点监测具有HTGW表型的人群。

Objective To study the relationship between hypertriglyceridemia-waist(HTGW)phenotype and high uric acidemia(HUA)and provide a basis for early identification of high-risk individuals of HUA.Methods Adults from 24 townships in Zhongshan City were selected by multi-stage random sampling method to conduct on-site questionnaires,physical examinations and biochemical index detection.The relationship between HTGW phenotype and HUA was analyzed using Logistic regression model,Goodman-Kruskal method and multivariate linear stepwise regression.Results A total of 7173 subjects were included.The detectable rate was 15.2%for the HTGW phenotype population and 2332 for HUA patients,with a detectable rate of 32.5%.The multi-factor Logistic regression analysis showed that the HTGW phenotype was an important risk factor for HUA(OR=2.689,95%CI:2.249-3.215,P<0.001).The results of the Goodman-Kruskal correlation analysis and Multiple linear regression modol showed that there was a significant positive correlation between the HTGW phenotype and HUA(P<0.001).Conclusions HTGW phenotype is an important risk factor of HUA.In daily prevention and treatment of HUA,we should focus on monitoring people with HTGW phenotype.