腹膜透析治疗终末期糖尿病肾病的临床效果研究

Study on the Clinical Effect of Peritoneal Dialysis in the Treatment of End-stage Diabetic Nephropathy

目的探究腹膜透析治疗终末期糖尿病肾病的临床效果。方法选取2018年7月—2020年6月在该院就诊的终末期糖尿病肾病患者作为研究对象,采用随机分组法,分为两组,各50例。观察组给予腹膜透析治疗,对照组给血液透析治疗,比较两组各项指标。结果观察组尿量(601.25±1.52)mL、血肌酐(431.25±2.85)umol/L、尿素氮(19.25±1.02)mmol/L、血红蛋白(105.25±2.52)g/L均高于对照组,差异有统计学意义(P<0.05)。观察组终末期糖尿病肾病患者不良事件发生率低于对照组,差异有统计学意义(P<0.05)。观察组治疗后总蛋白、血白蛋白、血钾水平均高于对照组,甲状旁腺激素(PTH)、血钙、血磷、血压水平均低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组糖尿病肾病患者在尿蛋白含量和尿微量白蛋白含量显著高于对照组患者,差异有统计学意义(P<0.05)。结论治疗终末期糖尿病肾病采用腹膜透析治疗效果显著,且能够降低不良事件发生率,改善患者肾功能,值得研究和推广。

Objective To explore the clinical effect of peritoneal dialysis in the treatment of end-stage diabetic nephropathy.Methods The patients with end-stage diabetic nephropathy who were treated in the hospital from July 2018 to June 2020 were selected as the subjects of this study.They were randomly divided into two groups,50 cases in each group.The observation group was treated with peritoneal dialysis and the control group was treated with hemodialysis.The indexes of the two groups were compared.Results The urine output(601.25±1.52)mL,blood creatinine(431.25±2.85)umol/L,urea nitrogen(19.25±1.02)mmol/L,and hemoglobin(105.25±2.52)g/L of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse events in patients with end-stage diabetic nephropathy in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total protein and blood albumin,blood potassium levels of the observation group after treatment were higher than those of the control group;the parathyroid hormone(PTH),blood calcium,blood phosphorus,and blood pressure levels were lower than those of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).In the observation group,the content of urinary protein and microalbuminuria in diabetic nephropathy patients were significantly higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of end-stage diabetic nephropathy using peritoneal dialysis has a significant effect,and can reduce the incidence of adverse events and improve the renal function of patients.It is worthy of research and promotion.