血清降钙素原应用在老年心衰合并肺炎患者抗感染治疗中的效果及不良事件发生率分析

Analysis of the Effect of Serum Procalcitonin in the Anti-infective Treatment of Elderly Patients with Heart Failure and Pneumonia and the Incidence of Adverse Events

目的探讨血清降钙素原应用在老年心衰合并肺炎患者抗感染治疗中的效果。方法选取2019年1月—2020年5月84例老年心衰合并肺炎患者,随机抽签分对照组与观察组,各42例,前者对症治疗,后者根据患者的血清降钙素原指标指导其治疗,对比两组患者的治疗效果。结果观察组的治疗效果与对照组比较(80.95%vs 78.57%),差异无统计学意义(χ^(2)=0.074,P>0.05);两组患者治疗后的CRP及ESR指标显著低于治疗前,差异有统计学意义(P<0.05);且观察组治疗后CRP指标为(12.72±2.22)mg/L,显著低于对照组的(18.32±3.22)mg/L,差异有统计学意义(t=9.279,P<0.05);观察组的PaO_(2)、PaCO_(2)、LVEF及BNP指标分别为(48.89±11.14)mmHg、(63.45±11.45)mmHg、(40.24±2.01)%及(889.15±23.45)pg/L,与对照组的(46.67±11.12)mmHg、(65.72±11.34)mmHg、(40.21±2.03)%及(893.48±23.67)pg/L比较,差异无统计学意义(P>0.05);84例患者培养出病原菌28例,总阳性率为33.33%,观察组病原菌阳性检出率35.71%,与对照组的30.95%比较,差异无统计学意义(χ^(2)=0.214,P>0.05);观察组不良事件发生率为7.14%,低于对照组,差异有统计学意义(χ^(2)=6.574,P<0.05)。结论心衰合并肺炎根据血清降钙素原指标指导其进行抗感染治疗,效果显著。

Objective To investigate the effect of serum procalcitonin in the anti-infection treatment of elderly patients with heart failure and pneumonia.Methods A total of 84 elderly patients with heart failure and pneumonia from January 2019 to May 2020 were randomly selected and divided into the control group and the observation group with 42 cases each.The former was treated symptomatically,and the latter was guided by the patient's serum procalcitonin index,Compared the treatment effect of the two groups of patients.Results The treatment effect of the observation group was not statistically significantly different from that of the control group(80.95%vs 78.57%)(χ^(2)=0.074,P>0.05);the CRP and ESR indexes of the two groups of patients after treatment were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the CRP index of the observation group after treatment was(12.72±2.22)mg/L,which was significantly lower than the control group's(18.32±3.22)mg/L,and the difference was statistically significant(t=9.279,P<0.05);the observation group’s PaO_(2),PaCO_(2),LVEF And BNP indicators were(48.89±11.14)mmHg,(63.45±11.45)mmHg,(40.24±2.01)%and(889.15±23.45)pg/L,respectively,compared with the control group's(46.67±11.12)mmHg,(65.72±11.34)mmHg,(40.21±2.03)%and(893.48±23.67)pg/L were not statistically significantly different(P>0.05);28 pathogenic bacteria were cultured in 84 patients,with a total positive rate of 33.33%.The observation group was positive for pathogenic bacteria was 35.71%,compared with 30.95%in the control group,there was no statistically significant difference(χ^(2)=0.214,P>0.05);the adverse event rate of 7.14%in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=6.574,P<0.05).Conclusion Heart failure complicated with pneumonia is guided by anti-infective treatment based on serum procalcitonin indicators,and the effect is significant.