缬沙坦与尼可地尔联合治疗高血压早期肾损害的效果

The Effect of Valsartan and Nicorandil in the Treatment of Early Renal Damage in Hypertension

目的讨论高血压早期肾损害治疗中缬沙坦与尼可地尔联合治疗的效果。方法选取该院2019年1月—2020年1月接诊收治的100例高血压早期肾损害患者为研究对象,参照病历号奇偶进行分组,观察组实施缬沙坦与尼可地尔联合治疗,对照组实施缬沙坦胶囊治疗,对比两组治疗前后肾损伤因子水平、凝血功能指标水平,统计两组疗效及不良反应发生率。结果治疗后,两组肾损伤因子水平均显著下降,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,观察组凝血功能指标水平与对照组对比,差异无统计学意义(P>0.05);治疗后,观察组凝血功能指标低于对照组,差异有统计学意义(P<0.05)。观察组临床疗效(98.00%)高于对照组(80.00%),差异有统计学意义(χ^(2)=8.274,P=0.004)。观察组1例患者发生心悸,不良反应发生率为2.00%,对照组1例患者发生消化道反应、2例头痛与下肢水肿、3例心悸,不良反应发生率为16.00%,观察组不良反应发生率低于对照组,差异有统计学意义(χ^(2)=4.396,P=0.036)。结论高血压早期肾损害临床治疗期间实施缬沙坦与尼可地尔联合治疗方案可切实改善患者肾损伤因子水平与凝血功能指标水平,提升疗效,降低不良反应发生率。

Objective To discuss the effect of valsartan and nicorandil in the treatment of early renal damage in hypertension.Methods 100 Early renal damage of hypertensive patients admitted and treated in the hospital from January 2019 to January 2020 as the research objects,grouped according to the medical record number,the observation group was treated with valsartan and nicorandil combined treatment,the control group with valsartan capsule treatment was performed,the levels of renal injury factors and blood coagulation index levels before and after treatment were compared between the two groups,and the efficacy and incidence of adverse reactions were counted.Results After treatment,the renal injury factor levels of the two groups decreased significantly,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).Before treatment,the coagulation function index level of the observation group was compared with the control group,and the difference was not statistically significant(P>0.05).After treatment,the coagulation function index of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The clinical efficacy of the observation group(98.00%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=8.274,P=0.004).Palpitations occurred in 1 patient in the observation group,and the adverse reaction rate was 2.00%.In the control group,1 patient experienced gastrointestinal reactions,2 headaches and lower extremity edema,and 3 cases of palpitations,the adverse reaction rate was 16.00%.The incidence of odverse roctions the observation group was lower than that of the control group,and the difference was statistically significant(χ^(2)=4.396,P=0.036).Conclusion During the clinical treatment of early renal damage of hypertension,the combined treatment of valsartan and nicorandil can effectively improve the levels of renal damage factors and coagulation function indicators,enhance the efficacy,and reduce the incidence of adverse reactions.