血清半乳糖凝集素3水平与房颤患者射频消融术后复发的相关性

Correlation between Serum Galectin 3 Level and Recurrence after Radiofrequency Ablation in Patients with Atrial Fibrillation

【目的】探讨半乳糖凝集素3(Gal-3)与房颤患者射频消融术后复发的相关性。【方法】选择2016年6月至2018年6月延安大学咸阳医院心内科收治的90例行射射频消融术治疗的房颤患者的临床资料,根据术后是否复发将其分为复发组(n=27)和未复发组(n=63)。采用夹心酶联免疫吸附荧光法检测血清Gal-3浓度,采用COX回归模型分析血清Gal-3水平对房颤消融术后复发的影响。【结果】90例房颤患者中持续性房颤48例(53.3%),24.4%的患者CHA2DS2-VASC评分>2分,在抗凝药物的使用上以华法林为主(60.0%)。复发组与未复发组患者年龄、房颤类型XHA2DS2-VASC评分、左心房直径(LAD)及血清氨基末端B型脑钠肽前体(NT-proENP)、高敏C反应蛋白(hs-CRP)、Gal-3水平比较,差异均有统计学意义(P<0.05)。单因素COX回归分析显示,年龄、LAD、持续性房颤及血清Gal-3、hs-CRP水平是房颤患者术后复发的危险因素(P<0.05)。多因素COX回归进一步分析显示,持续性房颤、LAD及血清Gal-3、hs-CRP水平是房颤患者RFCA术后复发的独立危险因素(P<0.05)。【结论】血清Gal-3水平是房颤患者行RFCA术后复发的独立危险因素,血清Gal-3高者复发风险大。

【Objective】To investigate the correlation between galectin-3(Gal-3)and recurrence after radiofrequency ablation in patients with atrial fibrillation.【Methods】The clinical data of 90 patients with atrial fibrillation treated by radiofrequency ablation in the Department of Cardiology of our hospital from June 2016 to June 2018 were selected.They were divided into recurrence group(n=27)and non recurrence group(n=63)according to whether they relapsed after operation.The concentration of serum Gal-3 was detected by sandwich enzyme-linked immunosorbent fluorescence method,and the effect of serum Gal-3 level on the recurrence of atrial fibrillation after ablation was analyzed by Cox regression model.【Results】Among the 90 patients with atrial fibrillation,48 patients(53.3%)had persistent atrial fibrillation,and 24.4%had CHA2DS2-VASC score>2.Warfarin was the main anticoagulant(60.0%).There were significant differences in age,type of atrial fibrillation,CHA2DS2-VASC score,left atrial diameter(LAD),serum amino terminal B^type probrain natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP)and Gal-3 between recurrent group and non recurrent group(P<0.05).Univariate Cox regression analysis showed that age,LAD,persistent atrial fibrillation and the levels of serum Gal-3 and hs-CRP were the risk factors for postoperative recurrence of atrial fibrillation(P<0.05).Multivariate Cox regression analysis showed that persistent atrial fibrillation,LAD and serum Gal-3 and hs-CRP levels were independent risk factors for recurrence after RFCA in patients with atrial fibrillation(P<0.05).【Conclusion】The level of serum Gal-3 is an independent risk factor for recurrence after RFCA in patients with atrial fibrillation.