2型糖尿病应用格列吡嗪控释片与阿卡波糖治疗的效果研究

Study on the Effect of Glipizide Controlled-release Tablets and Acarbose in the Treatment of Type 2 Diabetes

目的观察不同药物方案治疗2型糖尿病(T2DM)的效果。方法选择2019年5月—2020年3月收治的50例T2DM患者,按照随机原则分为甲、乙组,均给予阿卡波糖治疗,乙组在此基础上联合格列吡嗪控释片,比较治疗前后两组患者血糖、体质量变化及FINS、2 hPINS水平、临床有效率和不良反应发生情况。结果治疗后,乙组血糖FPG(6.2±1.5)mmol/L、2 hPG(8.3±3.4)mmol/L、HbA1c(7.1±1.0)%、BMI(21.4±1.8)kg/m^(2)均低于甲组,差异有统计学意义(P<0.05);两组FINS、2 hPINS水平比较,治疗后,乙组(9.66±3.15)、(33.14±6.70)mIU/L明显高于甲组,两组比较差异有统计学意义(P<0.05);乙组治疗总有效率为96.0%、不良反应发生率为8.0%均优于甲组,两组比较差异有统计学意义(P<0.05)。结论临床针对T2DM患者,推荐其采用格列吡嗪控释片与阿卡波糖联合用药治疗法,疗效确切,值得推广。

Objective To observe the effects of different drug regimens in the treatment of type 2 diabetes(T2DM).Methods Fifty patients with T2DM admitted from May 2019 to March 2020 were selected and divided into groups A and B according to the principle of randomization.Both groups were treated with acarbose,and group B was combined with glipizide controlled-release tablets on this basis,compare the changes in blood glucose,body weight,FINS,2 hPINS levels,clinical effective rates and adverse reactions between the two groups before and after treatment.Results After treatment,blood glucose FPG(6.2±1.5)mmol/L,2 hPG(8.3±3.4)mmol/L,HbA1c(7.1±1.0)%,and BMI(21.4±1.8)kg/m^(2) of group B were lower than those of group A,the difference was statistically significant(P<0.05);the levels of FINS and 2 hPINS between the two groups were compared.After treatment,the(9.66±3.15)mIU/L and(33.14±6.70)mIU/L of group B were significantly higher than those of group A.Comparison of the two groups had difference(P<0.05);the total effective rate of treatment in group B was 96.0%,and the incidence of adverse reactions was 8.0%better than that in group A.The difference between the two groups was statistically significant(P<0.05).Conclusion For T2DM patients,it is recommended to use glipizide controlled-release tablets and acarbose in combination therapy,which has a definite effect and is worthy of promotion.