摘要
报道了金属引导由N-(2-炔基芳基)内酰胺发散型合成羰基稠合的吲哚/吡咯的方法.该反应通过可调控的酰基正离子区域选择性傅-克环化反应进行,同时具有底物范围广,原子经济性和步骤经济性高等优势,有望用于含有相关结构的生物活性分子的合成.
A metal-guided method for divergent synthesis of ketone-fused indoles/pyrroles from N-(2-alkynylaryl)lactam is described.The reaction is proposed to proceed through a regioswitchable Friedel-Crafts cyclization of acylium.The obvious advantages are wide substrate scopes,high atom economy and step economy,which have a great potential in the synthesis of structure-related bioactive compounds.
作者
罗和江
曹同祥
祝诗发
Luo Hejiang;Cao Tongxiang;Zhu Shifa(Key Laboratory of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640;China-Singapore International Joint Research Institute,Guangzhou 510555)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第9期3521-3531,共11页
Chinese Journal of Organic Chemistry
基金
中华人民共和国科技部(No.2016YFA0602900)
国家自然科学基金(Nos.21871096,22071062,22001077)
广东省科学技术基金(Nos.2018B030308007,2018A030310359,2021A1515012331)
中国博士后科学基金(Nos.2018M643062,2019T120723)资助项目.
