灰叶南蛇藤的化学成分研究

Chemical Constituents of Celastrus glaucophyllus

目的:对灰叶南蛇藤进行化学成分研究。方法:对灰叶南蛇藤95%乙醇提取物的石油醚、乙酸乙酯部位分别采用硅胶、重结晶进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果:从灰叶南蛇藤中分离得到18个化合物,分别鉴定为:α⁃香树脂醇(1)、β⁃香树脂醇(2)、二十四酸(3)、β谷甾醇(4)、α⁃香树醇⁃3β⁃棕榈酸酯(5)、29⁃hydroxyfriedelan⁃3⁃one(6)、10⁃eicosenoic acid(7)、二十六烷(8)、鲨烯(9)、9⁃docosenamide(10)、rel⁃(3R,4S,5S)⁃3⁃[(2R)⁃2⁃hydroxynonadecanoyl]⁃4⁃hydroxy⁃5⁃[(4E)⁃heptadecane⁃4⁃ene]⁃2,3,4,5⁃tetrahydrofuran(11)、bis(2⁃ethylhexyl)benzene⁃1,2⁃dicarboxylate(12)、octadec⁃10Z⁃enoic acid(13)、celaphanol A(14)、regelindiol A(15)、雷公藤内酯甲(16)、直楔草酸(17)、槲皮素(18)。结论:所有化合物均为首次从该植物中分离得到。

Objective:To study the chemical constituents of Celastrus glaucophyllus.Methods:The petroleum ether and ethyl acetate parts of 95%ethanol extract of Celastrus glaucophyllus were isolated and purified by silica gel and recrystallization,respectively.The structures of the compounds were identified according to the physical and chemical properties and spectral data.Results:Eighteen compounds were isolated from Celastrus glaucophyllus and identified asα⁃amyrin(1)、β⁃amyrin(2)、tetracosanoic acid(3)、β⁃sitosterol(4)、α⁃aromadendrol⁃3β⁃palmitate(5)、29⁃hydroxyfriedelan⁃3⁃one(6)、10⁃eicosenoic acid(7)、hexacosane(8)、squalene(9)、9⁃do⁃cosenamide(10)、rel⁃(3R,4S,5S)⁃3⁃[(2R)⁃2⁃hydroxygennonadecanoyl]⁃4⁃hydroxy⁃5⁃[(4E)⁃heptadecane⁃4⁃ene]⁃2,3,4,5⁃tetrahydrofuran(11),bis(2⁃ethylhexyl)benzene⁃1,2⁃dicarboxylate(12),octadec⁃10Z⁃enoic acid(13),celaphanol A(14),regelindiol A(15),triptolide A(16),orthosphenic acid(17),quercetin(18),respectively.Conclusion:All compounds were isolated from Celastrus glaucophyllus for the first time.