C-3位五元螺环吲哚酮衍生物合成方法研究进展

Research Progress on the Synthetic Method of Five-Membered Spirooxindole Derivatives at C-3 Position

作为多种药物和天然产物的核心骨架结构,C-3位五元螺环吲哚酮衍生物在生物医药领域具有广泛的应用前景,实现该类化合物的高效不对称合成一直是有机化学家的研究热点.综述了近年来利用催化分子内反应、分子间反应和三组分反应不对称合成C-3位五元螺环吲哚酮衍生物的研究进展,并对该领域的未来发展方向进行了展望.

As the core skeleton structure of many drugs and natural products,spirooxindole derivatives have a wide range of applications in the field of biology and medicine.Efficient synthesis of spirooxindole derivatives with high enantioselectivity and diastereoselectivity has gained much attention in organic chemical community.In this paper,the asymmetric synthetic methods for C-3 five-membered spirooxindoles by catalytic intramolecular reactions,intermolecular reactions and threecomponent reactions are reviewed.The future development direction of this field is also prospected.