无配体参与的铁催化分子内C(sp^(3))-H键胺化合成咪唑啉酮

Ligand-Free Iron-Catalyzed Intramolecular Amination of C(sp^(3))-H Bond for the Synthesis of Imidazolinones

金属氮宾的分子内碳氢键插入反应是合成氮杂环最有效的方法之一.以2-叠氮基-N,N-二苄基乙酰胺为底物,发展了无配体、无外加氧化剂条件下的铁催化分子内sp3-碳氢键胺化反应,以中等到良好的收率合成了一系列咪唑啉酮类化合物.

Transition-metal-nitrenoids intramolecular C—H insertion is one of the most effective methods to synthesize nitrogen-containing heterocycles.Using 2-azido-N,N-dibenzylacetamides as substrates,an iron-catalyzed intramolecular C(sp3)—H bond amination reaction under ligand-free and external oxidant-free conditions has been developed.A series of imidazolinones were synthesized in moderate to good yields.