摘要
竞争性内源RNA(CeRNA)是纵横交错的调控网络,该网络可介导恶性肿瘤细胞表型,包括增殖和抑制、自噬、无限生长、诱导血管生成和血管生成拟态、免疫逃逸等。了解CeRNA介导恶性肿瘤表型调控及其功能,有望为恶性肿瘤提供新的诊断标志物和治疗靶点。
Competing endogenous RNAs(CeRNAs)are crisscrossing regulatory networks.CeRNAs networks can mediate malignant tumor cell phenotypes,including proliferation and inhibition,autophagy,infinite growth,induction of angiogenesis and angiogenic mimicosis,immune escape,etc..It is expected to provide new diagnostic markers and therapeutic targets for malignant tumors to master the regulation and function of CeRNAs mediated phenotype in malignant tumors.
作者
张静
黄守国
夏鹰
Zhang Jing;Huang Shouguo;Xia Ying(Department of Obstetrics and Gynecology,Haikou Municipal Hospital Affiliated to Xiangya Medical College of Central South University,Haikou 570208,China;Department of Neurosurgery,Haikou Municipal Hospital Affiliated to Xiangya Medical College of Central South University,Haikou 570208,China)
出处
《国际肿瘤学杂志》
CAS
2021年第9期544-548,共5页
Journal of International Oncology
基金
国家自然科学基金(81760234)
海南省自然科学基金(820QN424)。
