摘要
肿瘤来源的外泌体中存在丰富且稳定的环状RNA,其在肿瘤的发生发展中发挥重要作用。外泌体-环状RNA可作为肿瘤诊断和预后的标志物,并且在不同的肿瘤中具有调节肿瘤免疫反应、调控肿瘤进展和介导肿瘤耐药等作用。探索和应用外泌体-环状RNA潜在的价值将为肿瘤的诊治提供新的选择。
There are abundant and stable circular RNAs in tumor-derived exosomes,which play an important role in the occurrences and developments of tumors.Exosome-circRNAs can be used as the marker of tumors diagnosis and prognosis,and have different roles in regulating tumors immune responses,regulating tumors progressions and mediating tumors drug resistances in different tumors.Exploring and applying the potential value of exosome-circRNAs will provide a new choice for the diagnosis and treatment of tumors.
作者
张琬琛
徐加杰
张李卓
葛明华
Zhang Wanchen;Xu Jiajie;Zhang Lizhuo;Ge Minghua(Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Head and Neck Surgery,Zhejiang Provincial People's Hospital,Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province,Hangzhou 310014,China)
出处
《国际肿瘤学杂志》
CAS
2021年第9期549-552,共4页
Journal of International Oncology
基金
国家自然科学基金(81802674)
浙江省自然科学基金(LY21H160049)
浙江省医药卫生科学研究基金(2021419088)
浙江省中医药优秀青年人才基金(2018ZQ0100)。
